By George Tegos, Eleftherios Mylonakis

Drug resistance is expanding between a number of human pathogenic microorganisms corresponding to Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumaniii, Pseudomonas aeruginosa and Enterobacter spp. (currently dubbed the 'ESKAPE' pathogens), and has emerged as essentially the most very important scientific demanding situations of this century. elevated common wisdom and worry of those pathogens capacity there's a transforming into call for for learn to take on the specter of multidrug resistance. Documenting the most recent study within the box, this booklet discusses present and promising actions to find new antimicrobials in 5 key components: molecular genetics and platforms microbiology; artificial, computational chemistry and chemoinformatics; excessive Throughput Screening (HTS); non-vertebrate version hosts; and lightweight- and nano-based applied sciences.

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27 5. A major problem today is tuberculosis (TB) caused by Mycobacterium tuberculosis, which currently infects 2 billion people. TB was once considered to be disappearing; however, it has come back recently. There are two main reasons for this: the association of this bacterium with AIDS and the fact that M. tuberculosis strains resistant to several of the drugs used to treat the disease now predominate. Multiple drug resistance has developed against two of the most important TB drugs, rifampicin and isoniazid.

Soukos, N. M. (2011) Photodynamic therapy in the control of oral biofilms. Periodontology 2000 55, 143–166. V. and Gibbons, S. (2007) Bacterial efflux pump inhibitors from natural sources. Journal of Antimicrobial Chemotherapy 59, 1247–1260. , Bitter, W. M. (2011) Zebrafish embryo screen for mycobacterial genes involved in the initiation of granuloma formation reveals a newly identified ESX-1 component. Disease Models and Mechanisms 4, 526–536. A. G. (2010) Energy dose parameters affect antimicrobial photodynamic therapy-mediated eradication of periopathogenic biofilm and planktonic cultures.

Begun, J. M. (2005) The worm has turned – microbial virulence modeled in Caenorhabditis elegans. Trends in Microbiology 13, 119–127. , Chopra, I. W. (2010) Structure-based discovery of antibacterial drugs. Nature Reviews Microbiology 8, 501–510. , Roncucci, G. and Jori, G. (2002) Approaches to selectivity in the Zn(II)-phthalocyaninephotosensitized inactivation of wild-type and antibiotic-resistant Staphylococcus aureus. Photochemical and Photobiological Sciences 1, 815–819. Soukos, N. M. (2011) Photodynamic therapy in the control of oral biofilms.

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