By Feigal, Ellen G.

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However, the increase in AIDS cases in this group attests to their high risk of HIV infection. Although KS and NHL incidences increased, there was a decrease in both invasive and in situ cervical cancer and little change in the incidence of Hodgkin's disease.  However, the emerging understanding of the common role of human herpes virus type 8 (HHV­8; KSHV) in all forms of KS suggests that they are the same condition in all settings.  However, at least in nodular lesions (which could represent Page 28 the more­advanced form of this disease), the cells have now been shown to be clonal in origin (6), with lesions at different sites all derived from the same clone, which suggests metastasis (7).

However, the emerging understanding of the common role of human herpes virus type 8 (HHV­8; KSHV) in all forms of KS suggests that they are the same condition in all settings.  However, at least in nodular lesions (which could represent Page 28 the more­advanced form of this disease), the cells have now been shown to be clonal in origin (6), with lesions at different sites all derived from the same clone, which suggests metastasis (7).  In areas without adequate medical care, such as parts of Africa, secondary infections and disability are major contributors to mortality, even when the cancer is considered to be the primary cause of death.

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