By Deepak L. Bhatt, Anthony A Bavry

Acute coronary syndromes (ACS) is an umbrella time period used to explain a sequence of symptoms indicative of myocardial ischemia, comprising risky angina, non-ST section elevation myocardial infarction, and ST phase elevation myocardial infarction.

Managing Acute Coronary Syndromes in scientific perform is a vital source for the clinician within the administration of ACS. as well as supplying a finished review of the epidemiology and medical presentation of ACS, it additionally publications the reader via threat evaluate, hazard stratification, prognosis, and therapy of ACS. The publication concludes with a dialogue on rising applied sciences within the remedy of ACS. The instruction manual structure and considerable use of illustrations make this pocketbook an outstanding source for basic Practitioners, Emergency drugs Physicians, Nurses, Nurse Practitioners, Pharmacists, health care professional Trainees, scientific scholars, Nursing scholars, and Paramedics who desire to hold up to date with contemporary advances within the knowing and remedy of ACS.

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Extra info for Acute Coronary Syndromes in Clinical Practice

Example text

Further study of upstream versus deferred use of eptifibatide is underway in the EARLY ACS trial. Glycoprotein IIb/IIIa inhibitor recommendation Glycoprotein IIb/IIIa inhibitors are best suited for patients with ACS who undergo percutaneous coronary intervention [4,5]; however, conservatively treated patients with diabetes may also derive benefit from their use [26]. Abciximab appears to be preferred to the other agents when initiated in the catheterization laboratory and should be continued for 12 hours after intervention [31].

It is also important to understand that each drug comes with the potential for side effects. Accordingly, the risk–benefit profile for each cardiovascular drug should be known, and the side effects minimized where possible. For some patients, the risk of a drug will outweigh its expected benefit, and should therefore not be used. This chapter will review the important anti-platelet cardiovascular drugs across the spectrum of ACS and emphasize the benefits and side effects of each agent. Aspirin Aspirin is the unequivocal cornerstone of cardiovascular drugs.

J Am Coll Cardiol 2007; 49:1362–1368. , fondaparinux). The interest behind the use of anti-thrombin agents stems from the fact that ACS patients who are only treated with anti-platelet agents are still at risk of significant ischemic events. The clinical trial experience with these agents crosses several decades. , statins). This earlier time period was also largely characterized by noninvasive therapy, which is not currently considered the standard of care for ACS patients. Accordingly, the substantial improvement in medical therapy and invasive management of patients with ACS makes interpretation of the early trial experience relatively difficult, compared with the newer cardiovascular agents.

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